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Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa
(2006)
Aim: Continued surveillance of drug resistance amongst children presenting with culture-confirmed tuberculosis to a tertiary care hospital and to community clinics. Methods: Drug susceptibility testing for isoniazid and ...
Primary drug-resistant tuberculosis in children
(2000)
SETTING: The Western Cape Province of South Africa, an area with a high tuberculosis (TB) incidence where initial isoniazid (INH) resistance and multidrug resistance (MDR) among adults was 3.9% and 1.1%, respectively, ...
Childhood tuberculosis: Clinical research needs
(2004)
Childhood tuberculosis (TB) is common in the developing world, where over 90% of global TB cases occur, and has increased in human immunodeficiency virus (HIV) endemic regions. Most children with TB are not infectious, and ...
A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis
(2002)
SETTING: The diagnosis of tuberculosis (TB) in children is seldom confirmed, and is based mainly on clinical signs, symptoms and special investigations. Various attempts in the form of diagnostic approaches have been made ...
The spectrum of disease in children treated for tuberculosis in a highly endemic area
(2006)
BACKGROUND: Children contribute a substantial proportion of the global tuberculosis (TB) caseload, particularly in endemic areas, where little is known about their spectrum of disease. OBJECTIVE: To document the complete ...
The burden of childhood tuberculosis and the accuracy of community-based surveillance data
(2006)
BACKGROUND: Inadequate surveillance and diagnostic difficulties compromise the quality of epidemiological data on childhood tuberculosis (TB). OBJECTIVE: To document the incidence of childhood TB and to evaluate the accuracy ...
Management of children exposed to multidrug-resistant Mycobacterium tuberculosis
(2012)
Children exposed to multidrug-resistant (MDR) Mycobacterium tuberculosis are at risk of developing MDR tuberculosis. Where treatment is available, it is lengthy, expensive, and associated with poor adherence and notable ...
The 5-year outcome of multidrug resistant tuberculosis patients in the Cape Province of South Africa
(1996)
Little is known about the outcome of multidrug resistant (MDR) tuberculosis (TB) in developing countries. In this study, 443 patients with MDR-TB, defined as resistance to two Or more antituberculosis drugs, were identified ...
A prospective evaluation of children under the age of 5 years living in the same household as adults with recently diagnosed pulmonary tuberculosis
(1997)
SETTING: A South African suburb with a high tuberculosis incidence (>800/100 000). OBJECTIVE: To determine the prevalence of tuberculosis infection and disease in children less than 5 years of age who were in close household ...
Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa
(2006)
Drug resistance among children with culture-confirmed tuberculosis (TB) provides an accurate measure of transmitted drug resistance within the community. We describe the genotype diversity in children with culture-confirmed ...