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A multidisciplinary method to map potential tuberculosis transmission 'hot spots' in high-burden communities

Murray E.J. Marais B.J. Mans G. Beyers N. Ayles H. Godfrey-Faussett P. Wallman S. Bond V. (2009)

BACKGROUND: Global control of the tuberculosis (TB) epidemic remains poor, especially in high-burden settings where ongoing transmission sustains the epidemic. In such settings, a significant amount of transmission takes ...
Annual risk of tuberculous infection using different methods in communities with a high prevalence of TB and HIV in Zambia and South Africa

Shanaube K. Sisminidis C. Ayles H. Beyers N. Schaap A. Lawrence K.-A. Barker A. Godfrey-Faussett P. (2009)

Background: The annual risk of tuberculous infection (ARTI) is a key epidemiological indicator of the extent of transmission in a community. Several methods have been suggested to estimate the prevalence of tuberculous ...
Evaluation of the Capilia TB assay for culture confirmation of Mycobacterium tuberculosis infections in Zambia and South Africa

Muyoyeta M. De Haas P.E.W. Mueller D.H. Van Helden P.D. Mwenge L. Schaap A. Kruger C. Van Pittius N.C.G. Lawrence K. Beyers N. Godfrey-Faussett P. Ayles H. (2010)

The performance and cost of the Capilia TB assay were evaluated for use in a resource-limited setting. The sensitivity and specificity were 99.6% and 99.5%, respectively. The incremental costs of the Capilia test were ...
Potential utility of empirical tuberculosis treatment for HIV-infected patients with advanced immunodeficiency in high TB-HIV burden settings

Lawn S.D. Ayles H. Egwaga S. Williams B. Mukadi Y.D. Santos Filho E.D. Godfrey-Faussett P. Granich R.M. Harries A.D. (2011)

The human immunodeficiency virus (HIV) and HIV-associated tuberculosis (TB-HIV) epidemics remain uncontrolled in many resource-limited regions, especially in sub-Saharan Africa. The scale of these epidemics requires the ...
Prevalence of tuberculosis, HIV and respiratory symptoms in two Zambian communities: Implications for tuberculosis control in the era of HIV

Ayles H. Schaap A. Nota A. Sismanidis C. Tembwe R. De Haas P. Muyoyeta M. Beyers N. Godfrey-Faussett P. (2009)

Background: The Stop TB Partnership target for tuberculosis is to have reduced the prevalence of tuberculosis by 50% comparing 2015 to 1990. This target is challenging as few prevalence surveys have been conducted, especially ...
Risk factors associated with positive quantiFERON-TB gold in-tube and tuberculin skin tests results in Zambia and South Africa

Shanaube K. Hargreaves J. Fielding K. Schaap A. Lawrence K.-A. Hensen B. Sismanidis C. Menezes A. Beyers N. Ayles H. Godfrey-Faussett P. (2011)

Introduction: The utility of T-cell based interferon-gamma release assays for the diagnosis of latent tuberculosis infection remains unclear in settings with a high burden of tuberculosis. Objectives: To determine risk ...
Tuberculosis among community-based health care researchers

Claassens M.M. Sismanidis C. Lawrence K.-A. Godfrey-Faussett P. Ayles H. Enarson D.A. Beyers N. (2010)

BACKGROUND: Occupational tuberculosis (TB) in hospital-based health care workers is reported regularly, but TB in community-based health care researchers has not often been addressed. OBJECTIVE: To investigate TB incidence ...

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