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Characterization of HIV-1 subtype B near full-length genome sequences identified at the start of HIV epidemic in South Africa
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: South Africa is home to approximately 20.0% of the global Human Immunodeficiency Virus (HIV) infected population. The first reported cases of HIV-1 in the country were described in 1982 amongst the homosexual ... -
HIV-1 molecular diversity and drug resistance mutations amongst immuno-competent, therapy naïve infants/children and adults in Yaounde, Cameroon
(Stellenbosch : Stellenbosch University, 2017-12)Background: In Cameroon, HIV infections range between 550, 000 to 690, 000 for adults aged 15 to 49 years and a prevalence rate at 4.5%. In children of 0 – 14 years, HIV infections range between 34, 000 to 44, 000. The ... -
Investigating the fitness benefit of reverse transcriptase (RT) mutation A62V when co-occurring with M184V and K65R in HIV-1 subtype C
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Background and Aims Tenofovir disoproxil fumarate (TDF) and lamivudine (3TC) or emtricitabine (FTC) combined with efavirenz is the predominant first-line antiretroviral regimen in the Southern African ... -
Investigation of the HIV diversity in the Cape Winelands, Overberg and West Coast districts of the Western Cape Province of South Africa
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY: The Western Cape Province of South Africa has a well-established program that monitors active combination antiretroviral therapy (cART) against HIV-1. The HIV-1 prevalence rate in the Province has increased ...
