Now showing items 1-3 of 3
Gene expression changes in macrophages infected with pathogenic M. tuberculosis and non-pathogenic M. smegmatis and M. bovis BCG (Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: The current anti-TB drugs have had success in decreasing the number of deaths caused by TB, however, this success is limited by the emergence of drug resistant TB strains. Therefore, a novel TB therapy ...
Mycobacterium tuberculosis, a major threat to health in South Africa : intracellular survival after treatment with novel drugs designed against the mycothiol pathway (Stellenbosch : University of Stellenbosch, 2010-12)ENGLISH ABSTRACT: Mycothiol (MSH) is unique to mycobacteria as the major low molecular weight cellular thiol responsible for protection of bacteria against oxidative stress. The design of drugs and inhibitors against enzymes ...